Biology Faculty

Assistant Professor
PhD, Biomedical Sciences, Concentration in Molecular, Cellular, & Integrative Neurosciences, Colorado State University, 2007; BS, Biology, Chemistry Minor, Southern Oregon University, 2001

Teaching:

• Principles of Biology: Function and Ecology of Organisms (BI213)
• Comparative Animal Physiology (BI314)
• Neurophysiology (BI315)
• Pathogenesis and Pathophysiology (BI355)
• Advanced Animal Physiology (BI414)
• Neurodegeneration and Aging (BI430)

Research Interests

Dr. Paddock’s research focuses on synaptic function using a fruit fly (Drosophila), particularly examining the role of oxidative stress in nervous system function. Via this model, she has studied the role of synaptotagmin – a membrane-trafficking protein – in calcium-dependent synaptic transmission. Currently, her research focuses on the role of amyloid beta peptides in disrupting synaptic form and function, its dynamic production as a biomarker for disease progression, and the role of metals in amyloid production.

Publications

1. Paddock BE, Davenport C*. Positive Feedback Relationship between Lipid Peroxidation Offers Insights into the Pathogenesis of Alzheimer’s Disease. Journal of the Human Anatomy and Physiology Society. 2017 Dec; 21(3): 20-22.
2. Lembotesis MP*, Paddock BE, Cooper S. The Contralesional Repair Mechanism that leads to the Recovery of Motor Function After Ischemia in the Primary Motor Cortex. Journal of the Human Anatomy and Physiology Society. 2017 Aug; 21(2): 19-25.
3. Paddock BE, Canfield K*, Cooper S. Amyloid beta in the Cerebrospinal Fluid and the Blood as a Biomarker for Alzheimer’s Disease. Journal of the Human Anatomy and Physiology Society. 2015 Dec; 20(1): 38-43.
4. Mhatre SD, Satyasi V, Killen M*, Paddock BE, Moir RD, Sauders AJ, Marenda DR (2014) Synaptic abnormalities in a Drosophila model of Alzheimer’s disease. Dis Model Mech. 2014 Mar;7(3):373-85
5. Mhatre SD, Paddock BE, Saunders AJ, Marenda DR. (2013) Invertebrate Models of Alzheimer’s Disease. J Alzheimers Dis. 2013 Jan 1;33(1):3-16
6. Saunder A, Utreja A, Paddock B, Miller S, Marenda DR. (2012) Calcineurin inhibition alters APP metabolism in vitro and in vivo. Alzheimer’s and Dementia. 2012 July; 8(4): 209.
7. Chakraborty R, Vepuri V, Mhatre SD, Michelson SJ*, Delvadia R*, Desai A, Miller S, Vinokur M**,  Melicharek DJ, Paddock BE, Ansaloni S, Moir RD, Lee JC, Saunders AJ, and Marenda DR. (2011) Characterization of a Drosophila Alzheimer’s Disease Model: Pharmacological Rescue of Cognitive Defects. PLoS ONE. PLoS ONE 6(6): e20799. doi:10.1371/journal.pone.0020799
8. Paddock BE, Wang Z,  Biela LM, Chen K, Getzy MD, Striegel AR, Richmond JE, Chapman ER, Featherstone DE, Reist NE.  Membrane Penetration by Synaptotagmin is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo.  J Neurosci 2011 Feb 9; 31(6): 2248-57.
9. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo.  J Neurosci 2008 Jul 23; 28(30): 7458-66.
10. Lin JM, Kilman VL, Keegan K, Paddock B, Emery-Le M, Rosbash M, Allada R  A role for casein kinase 2alpha in the Drosophila circadian clock.  Nature 2002 Dec 19-26;420(6917-20).20).

Office: SC 383
Phone: 541.552.6864
E-Mail: paddockb@sou.edu